[{"@context":"https:\/\/schema.org\/","@type":"Article","@id":"https:\/\/www.okdxf.cz\/puvod-slabe-imunity\/#Article","mainEntityOfPage":"https:\/\/www.okdxf.cz\/puvod-slabe-imunity\/","headline":"P\u016fvod slab\u00e9 imunity","name":"P\u016fvod slab\u00e9 imunity","description":"N\u011bkte\u0159\u00ed lid\u00e9 mohou b\u00fdt n\u00e1chyln\u00ed k \u010dast\u011bj\u0161\u00edmu infek\u010dn\u00edmu onemocn\u011bn\u00ed, k nejr\u016fzn\u011bj\u0161\u00edm alergi\u00edm nebo maj\u00ed v\u011bt\u0161\u00ed \u0161ance trp\u011bt autoimunn\u00edmi onemocn\u011bn\u00edmi. Jak tato onemocn\u011bn\u00ed vznikaj\u00ed? To v\u011bdci st\u00e1le nev\u011bd\u00ed, av\u0161ak brn\u011bn\u0161t\u00ed specialist\u00e9 se tomu spole\u010dn\u011b s dal\u0161\u00edmi kolegy s\u00eddl\u00edc\u00edmi ve \u0160v\u00e9dsku, It\u00e1lii a Spojen\u00fdch st\u00e1tech americk\u00fdch usilovn\u011b v\u011bnuj\u00ed.
 
 Zat\u00edm zjistili jenom tolik, \u017ee se nejedn\u00e1 o...","datePublished":"2023-04-27","dateModified":"2023-04-27","author":{"@type":"Person","@id":"https:\/\/www.okdxf.cz\/author\/#Person","name":"okdxf.cz\n","url":"https:\/\/www.okdxf.cz\/author\/","identifier":1,"image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/664d9cd24f58d4d0b526991e1fec4656a216f6db124bbd66c69ade0e846d4f16?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/664d9cd24f58d4d0b526991e1fec4656a216f6db124bbd66c69ade0e846d4f16?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"okdxf.cz","logo":{"@type":"ImageObject","@id":"\/logo.png","url":"\/logo.png","width":600,"height":60}},"url":"https:\/\/www.okdxf.cz\/puvod-slabe-imunity\/","about":["Zdrav\u00ed"],"wordCount":421,"articleBody":"N\u011bkte\u0159\u00ed lid\u00e9 mohou b\u00fdt n\u00e1chyln\u00ed k \u010dast\u011bj\u0161\u00edmu infek\u010dn\u00edmu onemocn\u011bn\u00ed, k nejr\u016fzn\u011bj\u0161\u00edm alergi\u00edm nebo maj\u00ed v\u011bt\u0161\u00ed \u0161ance trp\u011bt autoimunn\u00edmi onemocn\u011bn\u00edmi. Jak tato onemocn\u011bn\u00ed vznikaj\u00ed? To v\u011bdci st\u00e1le nev\u011bd\u00ed, av\u0161ak brn\u011bn\u0161t\u00ed specialist\u00e9 se tomu spole\u010dn\u011b s dal\u0161\u00edmi kolegy s\u00eddl\u00edc\u00edmi ve \u0160v\u00e9dsku, It\u00e1lii a Spojen\u00fdch st\u00e1tech americk\u00fdch usilovn\u011b v\u011bnuj\u00ed.
 
 Zat\u00edm zjistili jenom tolik, \u017ee se nejedn\u00e1 o defekt jedin\u00e9ho genu; na vin\u011b je s nejv\u011bt\u0161\u00ed pravd\u011bpodobnost\u00ed s\u00e9rie n\u011bkolika genetick\u00fdch k\u00f3d\u016f.
 
 Co znamen\u00e1 selektivn\u00ed deficit IgA? 
 Zjednodu\u0161en\u011b to zna\u010d\u00ed, \u017ee se lidem, kte\u0159\u00ed t\u00edmto deficitem trp\u00ed, tvo\u0159\u00ed v t\u011ble nedostate\u010dn\u00e9 mno\u017estv\u00ed protil\u00e1tky \u201eimunoglobulin t\u0159\u00eddy A\u201c \u2013 to je z\u00e1kladn\u00ed protil\u00e1tka, je\u017e m\u00e1 za \u00fakol br\u00e1nit lidsk\u00fd organismus p\u0159ed infek\u010dn\u00edm onemocn\u011bn\u00edm.
 
 Progres autoimunn\u00ed nemoci 
 Tento deficit je pom\u011brn\u011b b\u011b\u017en\u00fd, ale neprojevuje se u v\u0161ech lid\u00ed. Av\u0161ak u n\u011bkter\u00fdch jedinc\u016f m\u016f\u017ee tento deficit gradovat a tvorba imunoglobulinu se tak m\u016f\u017ee zcela zablokovat. Tato porucha u\u017e je klasifikovan\u00e1 jako t\u011b\u017ek\u00e9 onemocn\u011bn\u00e9 imunitn\u00edho syst\u00e9mu, je\u017e b\u00fdv\u00e1 ozna\u010dov\u00e1na jako \u201eb\u011b\u017en\u00e1 variabiln\u00ed imunodeficience\u201c. Jedn\u00e1 se o t\u011b\u017ek\u00e9 onemocn\u011bn\u00ed, kter\u00e9 je z\u00e1rove\u0148 ojedin\u011bl\u00e9 – takov\u00e1to forma onemocn\u011bn\u00ed se vyskytuje jen z\u0159\u00eddka.
 
 V\u00fdzkum gen\u016f 
 Pr\u016fzkum na mase jedinc\u016f a jejich vy\u0161et\u0159en\u00ed, na n\u011bm\u017e se mimo italsk\u00fdch, \u0161v\u00e9dsk\u00fdch a americk\u00fdch v\u011bdc\u016f pod\u00edleli i ti \u010de\u0161t\u00ed, prok\u00e1zal, \u017ee tento deficit je \u00fazce propojen s geny, kter\u00e9 byly nov\u011b pops\u00e1ny a\u017e podle ned\u00e1vn\u00fdch odborn\u00fdch v\u00fdzkum\u016f a expert\u00edz; jedn\u00e1 se o produkty, kter\u00e9 vytv\u00e1\u0159ej\u00ed geny, je\u017e jsou sou\u010d\u00e1st\u00ed sign\u00e1ln\u00ed dr\u00e1hy spojen\u00e9 s produkc\u00ed imunoglobulinu IgA. To zna\u010d\u00ed, \u017ee vznik onemocn\u011bn\u00ed v\u00fd\u0161e uveden\u00fdch je chyba n\u011bkolika gen\u016f najednou a komplikace p\u0159i regulaci br\u00e1n\u011bn\u00ed vzniku autoimunitn\u00edho onemocn\u011bn\u00ed.
 
 Spolupr\u00e1ce v\u011bdc\u016f 
 Tento v\u00fdzkum zapo\u010dal ve \u0160v\u00e9dsku v institutu Karolinska. Experti z Brna s t\u00edmto institutem nav\u00e1zali \u00fazkou spolupr\u00e1ci ji\u017e p\u0159ed lety. Na t\u00e9to studii se pod\u00edleli v\u011bdci z \u00dastavu klinick\u00e9 imunologie a alergologie, specialist\u00e9 z Masarykovy univerzity, a tak\u00e9 Centrum kardiovaskul\u00e1rn\u00ed a transplanta\u010dn\u00ed chirurgie. 
                                                                                                                                                                                                                                                                                                                                                                                         3.7\/5 - (7 votes)        "},{"@context":"https:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"P\u016fvod slab\u00e9 imunity","item":"https:\/\/www.okdxf.cz\/puvod-slabe-imunity\/#breadcrumbitem"}]}]